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Id: | 26830
| Autor: | Martelli, Celina M. T; Stefani, Mariane M. A; Gomes, Maria Katia; Rebello, Paula F. B; Peninni, Silmara; Narahashi, Kasue; Maroclo, Ana Lucia O; Costa, Mauricio B; Silva, Simonne A; Sacchetim, Sylvana C; Nery, Jose Augusto C; Salles, Ana Maria; Gillis, Thomas P; Krahenbuhl, James L; Andrade, Ana Lucia S. S. | Título: | Single lesion paucibacillary leprosy: baseline profile of the Brazilian Multicenter Cohort Study.
| Fonte: | Int. J. Lepr;68(3):247-257, Sept., 2000. tab, graf, mapa.
| Resumo: | In Brazil, there is little information about the clinical and epidemiological characteristics of paucibacillary, single skin lesion leprosy patients (SSL-PB). Only recently has the official notification system distinguished leprosy patients with a single lesion as a clinical entity, for whom the single-dose ROM (rifampin, ofloxacin and minocycline) regimen has been recommended. In this paper, we describe the baseline clinical features and the immunological background of a multicenter cohort of SSL-PB leprosy cases enrolled between December 1997-1998. Patients were recruited at health centers located in the following regions: Southeast = Rio de Janeiro; North = Amazon and Rondônia states and Center-West = Goiás state. Eligible cases were newly detected, untreated single-lesion leprosy patients without thickened nerve involvement, and were assessed by clinical, bacilloscopic and histopathological exams. The Mitsuda skin test and anti-PGL-I serology (ELISA) were also performed. Of the 299 SSL-PB leprosy patients, 259 (86.6%) fulfilled the criteria for single-dose ROM intervention. Our results showed that patients recruited from different sites had similar features, considering the clinical and immunological profiles. There was a predominance of adults (mean age 32.4; S.D. = 16.0), and a BCG scar was detected in 76.7% of the children (< or = 15 years old). Only 7 cases were diagnosed as the multibacillary type, representing less than 3% of the patients being misclassified. Our data indicate that in Brazil SSL-PB case ascertainment based on clinical and bacilloscopic criteria can be accurately defined under a routine control program; 75.0% of SSL-PB cases were Mitsuda positive (> or = 5 mm) and seropositivity for anti-PGL-I was detected in 17.3% of the patients. These data are compatible with effective cell-mediated immunity and low bacillary load, suggesting favorable clinical outcomes for most SSL-PB participants of this cohort. (AU)^ien.
| Descritores: | Hanseníase Dimorfa/fisiopatol Hanseníase Virchowiana/fisiopatol Hanseníase Tuberculóide/fisiopatol Hanseníase/fisiopatol
| Meio Eletrônico: | http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n3/v68n3a01.pdf - en.
| Localização: | BR191.1 |
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